Current jobs related to Cell and Gene Therapy Technical Lead - Dublin, Dublin City - Ezimmerman

  • Senior Director, Global Patient Safety

    4 months ago

    Dublin, Ireland Regeneron Pharmaceuticals, Inc Full time

    Reporting to the Global Patient Safety (GPS) Therapeutic Area (TA) Head of General Medicines, the Senior Director is a key role that contributes to the success of Regeneron’s novel gene therapy approach. This position serves as the primary contact within the TA for all safety-related issues for the assigned compound(s) focusing mainly on supporting the...

  • Manager, Regulatory Intelligence

    2 months ago

    Dublin, Ireland Regeneron Pharmaceuticals, Inc Full time

    Regeneron is seeking a Manager to join the Regulatory Intelligence Group! In this role, a typical day might include: The Regulatory Intelligence Manager performs proactive global monitoring and surveillance of changes in the regulatory landscape focused on the drug development lifecycle, i.e., preclinical through commercialization, as well as...

  • Associate Director, RR COE Technical Lead

    4 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Associate Director, Supply Chain Product Lead

    3 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Postdoctoral researcher

    4 months ago

    Dublin, Ireland RCSI Full time

    Summary of Post Breast cancer brain metastases (BCBM) are a frequent and aggressive form of metastatic spread with limited treatment options. The successful candidate will join Prof Leonie Young and her team to identify the molecular mechanisms controlling the evolution of metastasis in breast cancer and define key regulators of metastatic spread. The...

  • Senior Manager, Quality Operations, Drug Product, EMEA and Asia Pacific

    4 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Technical Project Lead

    4 days ago

    Dublin, Ireland ATC Computer Transport & Logistics Full time

    Technical Project Lead RoleThe Technical Project Lead will act as the deputy to the Technical Programme Manager for Technical Services and will play a pivotal role in the success of the team. This individual will collaborate closely with internal stakeholders, cross-functional teams, and external clients, managing technical projects within the data centre...

  • Technical Lead

    1 month ago

    Dublin, Ireland NTT DATA Services Full time

    Req ID: 293912  NTT DATA Services strives to hire exceptional, innovative and passionate individuals who want to grow with us. If you want to be part of an inclusive, adaptable, and forward-thinking organization, apply now. We are currently seeking a Technical Lead (ETL) to join our team in Dublin, Dublin (IE-D), Ireland...

  • Technical Lead

    2 months ago

    Dublin, Ireland NTT DATA Services Full time

    Req ID: 293912 NTT DATA Services strives to hire exceptional, innovative and passionate individuals who want to grow with us. If you want to be part of an inclusive, adaptable, and forward-thinking organization, apply now.We are currently seeking a Technical Lead (ETL) to join our team in Dublin, Dublin (IE-D), Ireland (IE). SummaryThe Technical lead...

  • Technical Lead

    4 days ago

    Dublin, Ireland NTT DATA Services Full time

    NTT DATA Services strives to hire exceptional, innovative and passionate individuals who want to grow with us. If you want to be part of an inclusive, adaptable, and forward-thinking organization, apply now. SummaryProvides architectural direction, technical expertise and thought leadership to design, implement and manage the product delivery. Should...

  • Lead Technical Designer

    4 months ago

    Dublin, Ireland Playrix Full time

    Lead Technical Designer We at Playrix are certain that our success is the result of our talented team's efforts. We're looking for a Lead Technical Designer who will improve processes and be responsible for the management and development of their project's team. Together with other departments, you'll work on the technical component of our games —...

  • Senior Manager, Principal Scientist Packaging

    3 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • OIC Technical Lead/Architect

    1 week ago

    Dublin, Ireland Cpl Remote Work Freelance Full time

    Job Role: OIC Technical Lead/Architect/Designer: 12 month role, must be available onsite in Dublin up to 2 days a weekResponsibilities:Lead the end-to-end technical implementation of Oracle Integration Cloud projects, including requirements validation, aiding with design, development, testing and deployment.Collaborate with project managers, SMEs and other...

  • Technical Lead

    1 month ago

    Dublin, Ireland NTT DATA Services Full time

    NTT DATA strives to hire exceptional, innovative and passionate individuals who want to grow with us. If you want to be part of an inclusive, adaptable, and forward-thinking organization, apply now.   Summary of role: The successful candidate will be a valued member of the Business stakeholders team in a Core banking transformation project and...

  • Technical Lead

    1 month ago

    Dublin, Ireland NTT DATA Services Full time

    NTT DATA strives to hire exceptional, innovative and passionate individuals who want to grow with us. If you want to be part of an inclusive, adaptable, and forward-thinking organization, apply now. Summary of role:The successful candidate will be a valued member of the Business stakeholders team in a Core banking transformation project and will be...

  • PeopleSoft Technical Lead

    3 weeks ago

    Dublin, Ireland PartnerRe Full time

    Job DescriptionAbout this job:Reporting to the Head of IT Finance & Investments Services this role will support all technical aspects of PeopleSoft Finance and related ETLs as well as other finance applications to ensure stability and reliable internal & external reporting. As a member of the IT department combine strong development and administration...

  • Executive Director, Compliance Enabling QMS

    4 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Associate Director, Pharma MS&T Commercial Drug Product

    4 months ago

    Dublin, Ireland Bristol Myers Squibb Full time

    Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Technical Roaming Integrations Lead

    4 months ago

    Dublin, Ireland Cubic Telecom Full time

    Founded in 2009, Cubic Telecom has grown to become one of the leading providers of connectivity solutions and analytics services that help vehicle and IoT device manufacturers manage and grow revenue streams. Fast paced, smart, determined, and continually seeking new ideas. That’s us, is it you?  We are a leading cloud-based Machine to Machine (M2M)...

  • Power Platform Technical Lead

    2 weeks ago

    Dublin, Ireland Version 1 Full time

    Job DescriptionTechnical subject matter expertPlan, design, estimate, develop and implement Power Platform solutions based on established patterns and best practices, working with development teams as well as directly with customersLead technical development teams across different customer accounts, take ownership of deliverables and be responsible for the...

Cell and Gene Therapy Technical Lead

4 months ago

Dublin, Dublin City, Ireland Ezimmerman Full time

Alexion is committed to developing a variety of Genomic Medicines for the treatment of rare diseases. We have a portfolio of Adeno-Associated Virus (AAV) vectors that are being developed to deliver novel genetic therapies to patients for disease prevention and treatment, spanning multiple disease areas. We will also explore other Genomic Medicine modalities for the prevention and treatment of rare diseases, including non-viral vector delivery, Gene Editing, and ex vivo Cell Therapies.

Cell and Gene therapy manufacturing technology is advancing rapidly and the Alexion Operations team recognises that it is vital to have a robust manufacturing infrastructure in place to ensure that patients can access therapeutics as efficiently as possible.

We are seeking a highly experienced and motivated individual to join the Technical Operations team to help develop the manufacturing and supply strategy for these novel therapies and to provide technical input to the development of these products. This individual will work closely with other CMC and Operations functions to ensure harmonized strategies are executed to ensure on-time delivery of cell and gene therapy products through clinical development and through to launch.

You will be responsible for:

  • Provide leadership and support to the identification, evaluation and selection of partners for the supply and of starting materials, drug substance and drug product
  • Provide leadership and support to the identification, evaluation and selection of manufacturing technologies.
  • Providing technical leadership to the development of the manufacturing strategy for Alexion's Genomic Medicine portfolio, including input Make versus Buy decisions.
  • Serve as a Subject Matter Expert and establish internal guidelines, procedures and business processes for the manufacture of Genomic Medicines
  • Serve as a Subject Matter Expert during internal and external audits.
  • Assist Alexion's business development teams and serve as a Subject Matter Expert during due diligence of potential BD deals.
  • Partner with other CMC functions to create and implement a tech transfer, manufacturing and testing strategy for Contract and Development Manufacturing Organisations (CDMOs) services for viral vector and cell therapy production.
  • Partner with other CMC functions to ensure appropriate process design and process understanding for successful PPQ and commercial manufacturing
  • Provide oversight of external manufacturing activities at CDMOs to assure on-time supply of preclinical and clinical materials which meets quality, compliance, and regulatory requirements.
  • Continually update knowledge and understanding in the field of cell and gene therapy.

You will need to have:

  • BSc in Cell Biology, Biochemistry, Molecular Biology (or other gene therapy related field) with at least 15 years of experience in either the pharmaceutical industry or academic setting, with at least 5 years industry experience in the area of Cell or Gene Therapy.
  • In-depth knowledge of AAV product development and manufacturing and will have experience of transient transfection and producer cell line systems.
  • Prior experience of bringing Cell or Gene Therapy products through GMP manufacturing, validation and regulatory submission.
  • Strong knowledge of GMP practices and regulatory requirements from FDA and other global health authorities.
  • Strong leadership skills and demonstrated ability to collaborate and build relationships.
  • A strong understanding of the drug development pathway through commercialization and risk management, and ideally experience of bring a cell and gene therapy product to market.
  • The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

  • Higher degree (Masters /PhD) in Cell Biology, Biochemistry, Molecular Biology, Virology, Genetics or equivalent scientific discipline is preferred.

Proven track record of technical leadership in bringing Cell or Gene Therapy products through validation and reglatory approval

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.


#J-18808-Ljbffr