mRNA Technology Scientist

3 weeks ago

Dublin, Dublin City, Ireland Cpl Healthcare Full time
Cpl in partnership with our client Pfizer are seeking an mRNA Technology Scientist to join the team at their state of the art plant in Dublin, Grange Castle for an 11 month Fixed Term Contract. This is an onsite role.

What You Will Achieve

As a Scientist, you will be at the centre of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will provide science and technology expertise in the disciplines of messenger RNA (mRNA) in-vitro transcription and purification sciences for the development and optimization of vaccine manufacturing processes. You will help Pfizer develop new and improved processes used in the research and development of our drugs. Your innovative mindset will help us develop economical, efficient and safe chemical manufacture of experimental and active drug materials. Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. You are proactive in contributing to all team discussions and creating an environment of collaboration.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

1. Pfizer's Large Molecule Technology portfolio comprises multiple approaches for the creation of effective bio therapeutics. Technology advances have facilitated development of mRNA vaccines which are now a core component of Pfizer's product portfolio. mRNA vaccines have the potential to allow faster and more effective responses to infectious disease outbreaks.
2. This laboratory-based role will focus on the characterisation and improvement of these processes for existing mRNA vaccines in commercial manufacturing, and in the later stages of development programs at Pfizer. The Candidate will:

- Design and execute experimental studies for the development of mRNA vaccine including process characterisation and optimisation of process steps for plasmid DNA, mRNA drug substance and drug product manufacturing processes.
- Collaborate closely with analytical scientists who will work on the characterisation of these macromolecules during these process development studies.
- Work with the team in the design and optimisation of purification steps for mRNA vaccines using technologies such as filtration (normal/tangential flow), chromatography, etc.
- Provide technical support to Drug Substance Technical Services when required during investigations, new process introduction or change implementation in commercial manufacturing operations. Technical support may involve trouble-shooting manufacturing-scale process problems through experimental investigations at laboratory scales of operation.

Qualifications

Must-Have

- Minimum of +1 years' experience with a PhD or +3 years' experience with B.Sc./M.Sc. in the bio pharmaceutical industry.
- BSc/M.Eng/MSc/PhD in chemistry/biochemistry/biochemical engineering/analytical sciences or related discipline in the biochemical/manufacturing sciences.
- Technical fields of experience preferably to include specific knowledge and practical laboratory experience of mRNA bio processing and separation sciences, mammalian cell technology, biochemistry, cell biology, microbial fermentation, genetics, fluid mechanics and process modelling gained at a minimum at PhD level or through work experience.
- Experience in designing and executing components of experimental programs in the laboratory.
- Familiar with problem-solving, risk analysis and statistical tools.

Work Location Assignment: On Premise

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