Postdoctoral Fellow

RCSI - Royal College of Surgeons in Ireland

Organisation/Company: RCSI - Royal College of Surgeons in Ireland

Department: Human Resources

Research Field: Medical sciences » Health sciences

Researcher Profile: Recognised Researcher (R2)

Positions: Postdoc Positions

Country: Ireland

Application Deadline: 28 Feb 2025 - 23:45 (Europe/Dublin)

Type of Contract: Temporary

Job Status: Full-time

Hours Per Week: 39

Offer Description

Job Title: Postdoctoral Fellow (Parkinson’s Disease Experimental Research)

Department: Physiology & Medical Physics

Reporting to: Prof Jochen Prehn and Dr Niamh Connolly

Contract/Duration: Fulltime, contract for up to 23 months.

Remuneration: IUA Post-doctoral Researcher Level 1 pt 2

Closing Date: 28th Feb 2025

RCSI is a community of academic, research, clinical and professional staff working collaboratively to lead the world to better health. We invite you to join us to help deliver on our exciting mission “To educate, nurture and discover for the benefit of human health”. We seek candidates whose experience to date has prepared them to contribute to our commitment to the “Race Equality Action Plan 2021-2024” at RCSI.

About Our Research

RCSI recognises that excellence in research is critical to the quality of its educational activities. RCSI’s research strategy aims to build upon its strength in translational biomedical and clinical research to deliver transformational changes in health care.

Summary of Post

We are seeking a highly motivated and skilled post-doctoral researcher with strong experimental background in spatial/single-cell multi-omics, multiplex fluorescence imaging, and associated bioinformatics techniques. The ideal candidate should be capable of independently designing and executing experimental research, while collaborating within a multidisciplinary team.

Parkinson’s Disease is the fastest growing neurodegenerative condition worldwide. This post offers the opportunity to contribute to cutting-edge research aimed at transforming our understanding of Parkinson’s.

The JPND-funded 4DPD-Omics consortium is an international collaboration aimed to perform a comprehensive analysis of neuronal and non-neuronal responses to α-synuclein pathology in Parkinson’s.

Key objectives include:

- Correlating cellular transcriptome/proteome changes with α-Syn pathology progression.
- Identifying biomarkers and pathways in susceptible and resistant cell subtypes.
- Validating findings in clinical samples.
- Investigating disease pathways in the context of cell-type-specific responses.

Specifically, the duties of the post are:

- Prepare and process tissue slices for analyses.
- Lead high-throughput spatial transcriptomics studies.
- Implement and optimise spatial single-cell techniques.
- Perform multiplexed immunofluorescence imaging.
- Analyse spatial transcriptomics and proteomics data sets.
- Collaborate closely with RCSI researchers and external partners.
- Troubleshoot experimental challenges and maintain meticulous records.
- Communicate results through scientific publications and presentations.
- Ensure compliance with ethical guidelines.
- Undergo training and professional development activities as required.

Qualifications – (Essential):

- PhD (or submitted PhD thesis) in Biochemistry, Molecular Biology, Cell Biology or related discipline.
- Demonstrated expertise in spatial transcriptomics or similar techniques.
- Experience in translational research, particularly in neurodegenerative diseases.
- Proficiency in high-resolution molecular imaging techniques.
- Experience with tissue processing for advanced molecular analysis.
- Ability to analyze complex experimental data.
- A strong track record of impactful research.
- Excellent writing and interpersonal skills.
- A collaborative mindset.

Application Process

Please apply online through the RCSI careers portal before the closing date with your CV and cover letter detailing your applicable experience and motivation for applying for this role.

Employee Benefits

- Minimum of 20 days annual leave, plus an additional 6.5 Privilege days.
- Flexible/hybrid working options.
- 7% Employer pension contribution.
- Onsite gym.
- Childcare support.
- Employee assistance programme.
- Learning and Development training programmes.

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