Current jobs related to Postdoctoral Fellow - Dublin - RCSI

  • Postdoctoral Fellow

    4 months ago

    Dublin, Ireland RCSI Full time

    Post Date : 22-May-2024Close Date : 10-Jun-2024 Title: Postdoctoral Fellow Department: School of Population Health/Dept of General Practice, RCSI Tenure: Specified Purposes Contract for up to 24 months Salary: Appointable at Post-Doctoral Level 2b Scale Location: St Stephen’s Green, Dublin 2 Reporting to: Professor Kathleen Bennett / Professor...

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    Dublin, Ireland Trinity College Dublin Full time

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    2 months ago

    Dublin, Ireland Trinity College Dublin Full time

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  • Post-Doctoral Fellow

    3 months ago

    Dublin, Ireland RCSI Full time

    Summary of Post We are seeking to recruit a postdoctoral researcher to join the KK Lab in the School of Pharmacy & Biomolecular Sciences/Tissue Engineering Research Group at RCSI. The successful applicant will work primarily on an IRC-SFI funded project entitled “Nano-Engineered Biomaterial Delivery System with Controlled Strontium Release as a...

Postdoctoral Fellow

4 months ago

Dublin, Ireland RCSI Full time

Summary of Post

We are seeking to recruit a postdoctoral researcher to join the Cardiovascular Infection Research Group at RCSI. The successful applicant will work primarily on an NIH funded project focusing on the molecular mechanisms of heart valve damage during Infective Endocarditis. Project Brief: Infective endocarditis is a severe and potentially life-threatening infection that affects the inner lining of the heart chambers and heart valves. This condition occurs when bacteria, fungi, or other pathogens enter the bloodstream and latch onto the heart valves or other areas of the heart lining. Once attached, these microorganisms can rapidly multiply, leading to the formation of infected masses known as vegetations. These vegetations can damage heart tissues, disrupt blood flow, and cause a range of symptoms, including fever, fatigue, and heart murmurs. It is a complex medical condition that requires careful diagnosis and prompt treatment, as untreated cases can lead to serious complications, such as heart failure, stroke, or sepsis. Although Infective endocarditis can affect any of the heart tissues, the heart valves are by far the most common target. There are a number of reasons for this but primarily because the valves of the heart do not receive any dedicated blood supply. As a result, defensive immune mechanisms (such as white blood cells) cannot directly reach the valves via the bloodstream. If a bacteria attaches to valve surface and forms a vegetation, the host immune response is therefore blunted. To further compound this, the lack of blood supply to the valves also has implications on treatment, since drugs also have difficulty reaching the infected valve. Understanding the initial molecular interactions between the endothelial cells that line the heart tissues is essential to mitigating its potential consequences and improving patient outcomes.
Key to the survival of patients with infective endocarditis is the development of novel therapeutics that will improve patient outcomes. Many barriers exist in the development of such therapeutics to treat infective endocarditis with the primary cause centred around our poor understanding of the pathophysiology of the disease, particularly in the early stages of the disease. Infective endocarditis associated mortality is primarily related to the host response and although it is widely accepted there are complex interactions between various cell types, multitudes of inflammatory mediators and coagulation factors, clinical investigations have failed to identify suitable drug targets. Therefore, the primary hypothesis of this proposal is that we improve our basic understanding of the host response to bacterial infection of the heart valves using physiological 3D models in order to develop a next generation therapy that could surpass current interventions in the clinic for the treatment of heart infection and Infective Endocarditis. As platelets and the valvular endothelial cells plays a key role in mediating the Infective endocarditis phenotype we will focus on the potential value of these cells as a target for new therapy Click on the link(s) below to view documents Filesize 310.9