Neurovascular Senior Research Fellow

4 weeks ago

Dublin, Dublin City, Ireland Fastnet Full time
Overview

Our client in Dublin is looking for a Senior Research Fellow to join their team. This role offers a unique opportunity to contribute to the development of an innovative dual-cell therapy targeting neonatal hypoxia-associated brain injury. Neonatal hypoxic-ischaemic encephalopathy (HIE) is the second leading cause of infant mortality globally and a major contributor to long-term neurological conditions such as cerebral palsy, epilepsy, and sensory impairments. In Europe and the United States, HIE affects approximately 1 to 3 per 1,000 live births.

Responsibilities
  • Design, establish, and optimize in vitro hypoxia models relevant to neonatal brain injury.
  • Validate models for reproducibility and translational relevance.
  • Conduct proteomic and transcriptomic (RNA-seq) analyses to elucidate the mechanism of action (MoA) of MSC and ECFC co-therapy.
  • Integrate multi-omics data to identify key therapeutic pathways and biomarkers.
  • Define and characterize critical quality attributes (CQAs) for both MSCs and ECFCs, including identity, purity, viability, and immunophenotype.
  • Develop and implement robust assays to monitor CQAs.
  • Design and validate a potency matrix that reflects the therapeutic function of the dual-cell product.
  • Correlate potency metrics with MoA and preclinical efficacy data.
  • Develop release assays to ensure product consistency and compliance with regulatory standards.
  • Collaborate with consortium members to integrate assays into GMP and downstream activities.
  • Design and implement cell-based assays for functional characterisation and screening of therapeutic leads.
  • Analyse complex datasets from omics platforms and functional assays.
  • Lead and mentor a multidisciplinary research team, fostering collaboration and scientific excellence.
  • Lead and drive writing of manuscripts, grant reports, and regulatory submission contributions.
  • Present findings at consortium meetings, scientific conferences, and stakeholder briefings.
Qualifications
  • PhD in neuroscience, cell therapy, regenerative medicine, or a related scientific field and at least 6 years post-PhD experience in the field.
  • Clearly demonstrated leadership in research, a strong publication record in high-impact journals, presentation at international conferences, successful supervision of junior researchers and/or PhD students.
  • Proven experience in developing and validating in vitro and/or in vivo models of hypoxia or neurovascular injury.
  • Strong expertise in cell biology, particularly with mesenchymal stromal cells (MSCs) and endothelial colony-forming cells (ECFCs).
  • Demonstrated experience in proteomics and transcriptomics (e.g., RNA-seq) for mechanism of action studies.
  • Experience in defining and assessing critical quality attributes (CQAs) such as identity, purity, and viability.
  • Track record in developing potency assays and release criteria for advanced therapy medicinal products (ATMPs).
  • Hands-on experience with neuronal models and their application in neurodegenerative or neurodevelopmental research.
  • Familiarity with neurovascular models and the study of vascular–neural interactions in health and disease.
  • Experience in leading or mentoring research staff or students.
Details
  • Seniority level: Mid-Senior level
  • Employment type: Contract
  • Job function: Research

#J-18808-Ljbffr

  • Senior Research Fellow

    4 weeks ago

    Dublin, Dublin City, Ireland Royal College of Surgeons (RCSI) Full time

    Job Title: Senior Research Fellow (50% FTE) Department: School of Population Health Reporting to: Prof. Breda Smyth Location: RCSI, Dublin 2 Contract/Duration: Specified purpose, Part-time (50% FTE), up to 12 months (with option to extend to 18 months) Remuneration: Post will be appointed on the Research Fellow/Snr Research Fellow Salary Scale, commensurate...

  • Postdoctoral Research Fellow

    4 weeks ago

    Dublin, Dublin City, Ireland UNSW Full time

    Postdoctoral Research Fellow (Indigenous Targeted) - Culturally Nourishing School2 days ago Be among the first 25 applicantsWe strongly encourage Aboriginal and Torres Strait Islander people to apply.The Culturally Nourishing Schooling (CNS) project is a collaborative initiative between universities, schools, and communities, supporting Aboriginal and Torres...

  • Senior Research Fellow in Computer Science

    4 weeks ago

    Dublin, Dublin City, Ireland Royal College of Surgeons (RCSI) Full time

    Job Title: Software Architect/Full Stack developer in Digital Health/ Senior Research Fellow in Computer Science Department: School of Physiotherapy Reporting to: Dr. Grace O'Malley Location: RCSI, St Stephen's Green, Dublin 2 Contract/Duration: Specific purpose 0.5 WTE post for 12 months Remuneration: Aligned with IUA Senior Research Fellow Salary Scale...

  • Postdoctoral Fellow

    4 weeks ago

    Dublin, Dublin City, Ireland UNSW Full time

    Join to apply for the Postdoctoral Fellow - Chemistry role at UNSW1 day ago Be among the first 25 applicantsJoin to apply for the Postdoctoral Fellow - Chemistry role at UNSWGet AI-powered advice on this job and more exclusive features.One of Australia's leading research & teaching universitiesVibrant campus life with a strong sense of community &...

  • Senior Research Fellow

    4 weeks ago

    Dublin, Dublin City, Ireland Unist Full time

    OverviewOrganisation/Company RCSI - Royal College of Surgeons in IrelandDepartment Human ResourcesResearch Field Medical sciences » Health sciencesResearcher Profile Established Researcher (R3)Positions Postdoc PositionsCountry IrelandApplication Deadline 25 Sep 2025 - 23:45 (Europe/Dublin)Type of Contract TemporaryJob Status Part-timeHours Per Week 19.5Is...

  • Postdoctoral Research Fellow In Behavioural Science

    3 weeks ago

    Dublin, Dublin City, Ireland The Behavioral Economics Group Full time

    The Behavioural Research Unit at the Economic and Social Research Institute (ESRI) wishes to appoint a Postdoctoral Research Fellow.Candidates will be considered from a range of disciplines, including but not limited to behavioural economics, experimental psychology, and decision science.This is a 3-year fixed-term position.The InstituteThe ESRI, founded in...

  • Ad Astra Fellow

    4 weeks ago

    Dublin, Dublin City, Ireland European Federation Of Organizations For Medical Physics - Efomp Full time

    Ad Astra Fellow - Assistant Professor in Medical PhysicsPosition:Institution: University College DublinLocation: Dublin, IrelandApplication closes at: Feb 21st, 2025 12:00The School of Physics, through its Centre for Physics in Health and Medicine (CPHM), has established a multi-disciplinary environment of researchers for the translation of fundamental...

  • Quantitative Research Director

    4 weeks ago

    Dublin, Dublin City, Ireland Research Ltd Full time

    RED C Research Group are one of the UK and Ireland's premier providers of research-based consultancy services and political polling, serving clients worldwide. Founded in Dublin in 2003, it now has more than 85 staff, and with consistent growth over the last number of years its revenues place it in the top 125 market research groups globally. The company is...

  • Vacancy For Teaching Fellow In Library And Information Studies At Ucd

    3 weeks ago

    Dublin, Dublin City, Ireland Digital Preservation Coalition Full time

    Vacancy for Teaching Fellow in Library and Information Studies at UCDVacancy for Teaching Fellow in Library and Information Studies at UCD26 July 2021Fixed TermTeaching Fellow in Library and Information Studies, UCD School of Information and Communication Studies, 1 year postApplications are invited for a1 yearpost of aTeaching FellowinLibrary and...

  • Vacancy for Teaching Fellow in Library and Information Studies at UCD

    4 weeks ago

    Dublin, Dublin City, Ireland Digital Preservation Coalition Full time

    Vacancy for Teaching Fellow in Library and Information Studies at UCDVacancy for Teaching Fellow in Library and Information Studies at UCD26 July 2021Fixed TermTeaching Fellow in Library and Information Studies, UCD School of Information and Communication Studies, 1 year postApplications are invited for a1 yearpost of aTeaching FellowinLibrary and...