Neurovascular Senior Research Fellow

4 days ago

Dublin, Dublin City, Ireland Fastnet Full time
Overview

Our client in Dublin is looking for a Senior Research Fellow to join their team. This role offers a unique opportunity to contribute to the development of an innovative dual-cell therapy targeting neonatal hypoxia-associated brain injury. Neonatal hypoxic-ischaemic encephalopathy (HIE) is the second leading cause of infant mortality globally and a major contributor to long-term neurological conditions such as cerebral palsy, epilepsy, and sensory impairments. In Europe and the United States, HIE affects approximately 1 to 3 per 1,000 live births.

Responsibilities
  • Design, establish, and optimize in vitro hypoxia models relevant to neonatal brain injury.
  • Validate models for reproducibility and translational relevance.
  • Conduct proteomic and transcriptomic (RNA-seq) analyses to elucidate the mechanism of action (MoA) of MSC and ECFC co-therapy.
  • Integrate multi-omics data to identify key therapeutic pathways and biomarkers.
  • Define and characterize critical quality attributes (CQAs) for both MSCs and ECFCs, including identity, purity, viability, and immunophenotype.
  • Develop and implement robust assays to monitor CQAs.
  • Design and validate a potency matrix that reflects the therapeutic function of the dual-cell product.
  • Correlate potency metrics with MoA and preclinical efficacy data.
  • Develop release assays to ensure product consistency and compliance with regulatory standards.
  • Collaborate with consortium members to integrate assays into GMP and downstream activities.
  • Design and implement cell-based assays for functional characterisation and screening of therapeutic leads.
  • Analyse complex datasets from omics platforms and functional assays.
  • Lead and mentor a multidisciplinary research team, fostering collaboration and scientific excellence.
  • Lead and drive writing of manuscripts, grant reports, and regulatory submission contributions.
  • Present findings at consortium meetings, scientific conferences, and stakeholder briefings.
Qualifications
  • PhD in neuroscience, cell therapy, regenerative medicine, or a related scientific field and at least 6 years post-PhD experience in the field.
  • Clearly demonstrated leadership in research, a strong publication record in high-impact journals, presentation at international conferences, successful supervision of junior researchers and/or PhD students.
  • Proven experience in developing and validating in vitro and/or in vivo models of hypoxia or neurovascular injury.
  • Strong expertise in cell biology, particularly with mesenchymal stromal cells (MSCs) and endothelial colony-forming cells (ECFCs).
  • Demonstrated experience in proteomics and transcriptomics (e.g., RNA-seq) for mechanism of action studies.
  • Experience in defining and assessing critical quality attributes (CQAs) such as identity, purity, and viability.
  • Track record in developing potency assays and release criteria for advanced therapy medicinal products (ATMPs).
  • Hands-on experience with neuronal models and their application in neurodegenerative or neurodevelopmental research.
  • Familiarity with neurovascular models and the study of vascular–neural interactions in health and disease.
  • Experience in leading or mentoring research staff or students.
Details
  • Seniority level: Mid-Senior level
  • Employment type: Contract
  • Job function: Research

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