SFI Postdoctoral Fellow

2 days ago


Dublin, Ireland Royal College of Surgeons (RCSI) Full time

Job Title: SFI Postdoctoral Fellow Department: Vascular Biology, School of Pharmacy and Biomolecular Sciences Reporting to: Professor James O'Donnell Location: RCSI Dublin Contract/Duration: Specified purpose contract for 12 months Remuneration: Post Doctoral researcher scale, depending on experience Closing Date: Sunday, 30th of March 2025 RCSI is a community of academic, research, clinical and professional staff working collaboratively to lead the world to better health. Here, you will thrive in an innovative and inclusive atmosphere and your personal development and wellbeing will be supported. We invite you to join us to help deliver on our exciting mission "To educate, nurture and discover for the benefit of human health". We seek candidates whose experience to date has prepared them to contribute to our commitment to the "Race Equality Action Plan 2021-2024" at RCSI. Our students come from all walks of life and so do we. We hire great people from a wide variety of backgrounds. This makes our university stronger and ensures we hire the best talent. Innovating for a Healthier Future 2023-2027 is RCSI's new five-year strategic plan. Through it, RCSI will enhance human health by meeting the health workforce needs of society, creating the insights and inventions that drive health improvements, and working in partnership with patients and the public in support of better health and well-being for all. The strategy unites the RCSI community in supporting the UN Sustainable Development Goals - with a particular focus on Goal 3, which targets good health and well-being. For each of the last six years, RCSI has been positioned in the Top 300 of universities worldwide in the Times Higher World University Rankings. We are proud that RCSI ranks fifth in the world for "Good Health and Well-being" in the Times Higher Education #SDG #SDG Impact Rankings 2024. This reflects our commitment to supporting people of all ages to live healthy lives and our work to promote the concepts of well-being and positive health. Our values of Respect, Collaboration, Scholarship and Innovation continue to unite and direct our purpose. About Our Research RCSI recognises that excellence in research is critical to the quality of its educational activities, its credibility, and, overall, to its mission to enhance human health. RCSI's research strategy aims to build upon its strength in translational biomedical and clinical research to deliver transformational, high impact changes in health care. Targeting both Irish national and EU funding, along with increased collaboration with industry, is a major part of the RCSI research strategy. Forging increased collaboration between RCSI PIs and industry is of critical importance to achieving success in this area. RCSI is also committed to provide its researchers with the supports and developmental opportunities to enable them to continuously grow and support their overall career development. Summary of Post Applications are invited for a Post Doctoral Fellow position on a prestigious new Science Foundation Ireland funded project entitled "Developing novel therapeutics to increase plasma von Willebrand factor levels for patients with the inherited bleeding disorder von Willebrand disease". VWD is the commonest inherited human bleeding disorder. It affects both males and females, with an estimated population prevalence of approximately 1 per 1000 people around the world. People with VWD experience lifelong bleeding. This bleeding can be spontaneous (e.g. nose bleeds, gum bleeding or easy bruising) or can be life-threatening following major surgery or around the time of delivery of a baby. Heavy menstrual bleeding (HMB) is common in women with VWD. Unfortunately, this HMB burden is massively under-recognised and consequently continues to be associated with huge global morbidity. For example, HMB in young women with VWD causes missed days from school and work, leads to iron deficiency, and thus has major socio-economic consequences for affected individuals. This project aims to develop new therapies to reduced bleeding in VWD patients. The PostDoc will join an established team of 5 experienced post-doctoral fellows all working in the world-leading RCSI Irish Centre for Vascular biology which is directed by Professor James O'Donnell. This research team (n=8) has been working on VWD for more than 20 years and has published more than 220 papers on this subject in high-impact journals. The role will include working on a wide range of state-of-the-art laboratory methodologies spanning molecular biology and cellular biology and will also provide opportunities to engage with VWD patients attending the National Coagulation Centre in St James's Hospital, Dublin. Based on the insights derived from the exciting plan of investigation, we aim to improve the clinical treatment for patients with VWD both in Ireland and around the world. Our ultimate ambition is to develop novel therapeutic strategies that will be useful in preventing bleeding complications and improving quality of life for individuals with VWD. Specifically, the duties of the post are: Conduct a specified programme of research under the supervision and direction of the Principal Investigator Disseminate the results of the research in which you are engaged in, as directed by the Principal Investigator Carry out administrative work associated with your programme of research Undertake appropriate training and development as required by the Principal Investigator, School and/or College Qualifications - (Essential): Primary Degree in Molecular Biology/Biochemistry/Genetics or related biological subject Knowledge & Experience: Those with experience of animal husbandry and care of the mice colonies; the breeding of transgenic colonies and compliance with directives set out by the HPRA are encouraged to apply (desirable) Experience in current molecular biology techniques, protein biochemistry (desirable) Experience in the area of vascular biology, haemostasis and immunology (desirable) Strong research record including publications (relative to career stage) Be highly motivated and dynamic Excellent communication and interpersonal skills An ability to work with a multidisciplinary team Be self-motivated, creative and highly competent, as evidenced by publication in recognised journals We are all too aware that imposter syndrome and the confidence gap can sometimes stop fantastic candidates putting themselves forward, so please do submit an application - we'd love to hear from you. Application Process Please apply online through the RCSI careers portal on the closing date with your CV and cover letter. Please note we do not accept CVs directly.



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