Postdoctoral Fellow
2 weeks ago
Closing Date: 28 Feb 2025
Address: RCSI, St. Stephen's Green, Dublin 2, Ireland
Duration: Fulltime, contract for up to 23 months
Summary of Post:
We are seeking a highly motivated and skilled post-doctoral researcher with a strong experimental background in spatial/single-cell multi-omics, multiplex fluorescence imaging, associated bioinformatics techniques, and complementary systems modelling. The ideal candidate should be capable of independently designing and executing experimental research while collaborating within a multidisciplinary team.
Parkinson's Disease is the fastest growing neurodegenerative condition worldwide, yet the gold standard treatment has remained largely unchanged for the last 50 years. The disease is characterised by the progressive degeneration of specific neuronal populations, such as dopaminergic neurons in the substantia nigra pars compacta. This post offers the opportunity to contribute to cutting-edge research aimed at transforming our understanding of Parkinson's.
The JPND-funded 4DPD-Omics consortium is an international collaboration of experts in α-Synuclein biochemistry, neuroanatomy, neuropathology, disease modelling, spatial and single-cell omics, bioinformatics, and systems biology. The project will utilise well-characterized preclinical models and clinically annotated human postmortem samples spanning Braak stages 0-VI. Key objectives include:
1. Correlating cellular transcriptome/proteome changes with α-Syn pathology progression.
2. Identifying biomarkers, pathways, and master regulators in susceptible and resistant cell subtypes.
3. Validating findings in clinical samples using high-resolution multiplexing approaches.
4. Systematically investigating disease pathways in the context of cell-type-specific responses.
Responsibilities:
• Prepare and process tissue slices from pre-clinical models and human post mortem samples for spatial/single-cell transcriptomic/proteomic analyses and multiplex fluorescence imaging.
• Lead high-throughput spatial transcriptomics studies using the GeoMx Digital Spatial Profiler.
• Implement and optimise spatial single-cell transcriptomics/proteomics techniques.
• Perform multiplexed immunofluorescence imaging (MxIF) and CellDIVE hyperplexing.
• Analyse spatial transcriptomics and proteomics datasets.
• Collaborate closely with RCSI researchers and external partners.
• Troubleshoot experimental challenges and maintain meticulous experimental records.
• Communicate results through scientific publications and presentations.
• Ensure compliance with ethical guidelines for animal research and handling of human tissue samples.
• Undergo training and professional development activities as required.
Qualifications – (Essential):
• PhD (or submitted PhD thesis) in Biochemistry, Molecular Biology, Cell Biology or related discipline, ideally in the field of neuroscience.
• Demonstrated expertise in spatial transcriptomics, single-cell RNA sequencing, or similar advanced molecular techniques.
Knowledge & Experience – (Essential):
• Demonstrated expertise in high-throughput spatial transcriptomics experiments.
• Proficiency in high-resolution molecular imaging techniques.
• Experience with tissue processing for advanced molecular analysis.
• A strong track record of impactful research, evidenced by high-quality publications.
Application Process:
Please apply online through the RCSI careers portal before the closing date with your CV and cover letter detailing your applicable experience and motivation for applying for this role.
Further Information
RCSI is a community of academic, research, clinical and professional staff working collaboratively to lead the world to better health. We invite you to join us to help deliver on our exciting mission "To educate, nurture and discover for the benefit of human health".
Informal Enquiries can be directed to Niamh Connolly: niamhmconnolly@rcsi.com. Please note we do not accept CVs directly.
#J-18808-Ljbffr
-
Postdoctoral Fellow
2 days ago
Dublin, Dublin City, Ireland RCSI Full timePost Date : 22-May-2024Close Date : 23-Jun-2024 Title: Postdoctoral Fellow Department: School of Population Health/Dept of General Practice, RCSI Tenure: Specified Purposes Contract for up to 24 months Salary: Appointable at Post-Doctoral Level 2b Scale Location: St Stephen's Green, Dublin 2 Reporting to: Professor Kathleen Bennett / Professor...
-
Postdoctoral Fellow
3 weeks ago
Dublin, Dublin City, Ireland British Neuroscience Association Full timeTo advertise your Job Opportunities on the BNA website, please log in and click the link above.Postdoctoral Fellow (Parkinson's Disease Computational Research)Closing Date: 28 Feb 2025Address: RCSI, St. Stephen's Green, Dublin 2, IrelandDuration: Fulltime, contract for up to 23 months.Summary of Post:We are seeking a highly motivated and skilled...
-
Research Fellow
2 weeks ago
Dublin, Dublin City, Ireland TN Ireland Full timePost SummaryWe are seeking to recruit a Postdoctoral Research Fellow (20 month contract) for the research project 'INTUIT'. The successful candidate will join an interdisciplinary team of researchers undertaking research in the area of telecommunications development and the environment. The post will be situated in the School of Engineering, Trinity College...
-
Dublin, Dublin City, Ireland Beck Region - Modern Woodmen of America Full timePostdoctoral: School of Engineering: The School of Engineering at Trinity College Dublin, in collaboration with the Science Foundation Ireland CONNECT Centre, is excited to announce a vacancy for a Postdoctoral Research Fellow. This is part of the "Not A Space Race," a cutting-edge 2-year project focusing on the study and perception of quantum technologies...
-
Dublin, Dublin City, Ireland DALLAS VA RESEARCH CORPORATION Full timeResearch Fellow in Organic Chemistry: Trinity College Dublin's School of Chemistry invites applications for a postdoctoral position within the Porphyshape project, focusing on the Molecular Engineering of Functional Organic Materials. This SFI funded project, led by Prof. Mathias O. Senge, aims to challenge conventional limitations of metalloporphyrins by...
-
Dublin, Dublin City, Ireland Findauniversity Ltd. Full timeNEUROADAPT Marie-Sklodowska Curie Postdoctoral Fellowships (Ireland / Global)Royal College of Surgeons in IrelandDeadline:11 April 2025Salary: €57,000 to €65,000 with allowances depending on host and applicant status.Call open: 15th January 2025, 09.00hrs (GMT)Submission Deadline: 11th April 2025, 17.00hrs (GMT)About the ProgrammeNeuroadapt is a Marie...
-
Dublin, Dublin City, Ireland Dublin Institute for Advanced Studies Full timePostdoctoral Fellowship with the DIAS Solar Physics GroupApplications are invited for a Postdoctoral Fellowship at the Dublin Institute for Advanced Studies (DIAS) in the Astronomy & Astrophysics Section working with the Solar Physics and Space Weather group. The Astronomy & Astrophysics Section is a vibrant and inclusive community of researchers working on...
-
Dublin, Dublin City, Ireland Findauniversity Ltd. Full timePost doc/ Research Fellow in Bioinformatics/Botany/Plant PathologyBotany, School of Natural Sciences, University of Dublin, Trinity College, IrelandDeadline:17 March 2025£45,847 to £47,273 Irish Universities Association, Postdoctoral Researcher Level 1, point 1A postdoctoral researcher is required with knowledge and experience in bioinformatics/high...
-
Research Fellow in Computer Science
1 week ago
Dublin, Dublin City, Ireland Trinity College Dublin Full timeTrinity is Ireland's leading university and is ranked 87th in the world (QS World University Rankings 2025). Founded in 1592, the University is steeped in history with a reputation for excellence in education, research, and innovation, which has been inspiring generations of thinkers for over 400 years. A postdoctoral researcher position is available with...
-
Post-Doctoral Fellow
2 days ago
Dublin, Dublin City, Ireland RCSI Full timeSummary of Post We are seeking to recruit a postdoctoral researcher to join the KK Lab in the School of Pharmacy & Biomolecular Sciences/Tissue Engineering Research Group at RCSI. The successful applicant will work primarily on an IRC-SFI funded project entitled "Nano-Engineered Biomaterial Delivery System with Controlled Strontium Release as a Reparative...
-
15h Left) Machine Learning Researcher Fellowship
2 weeks ago
Dublin, Dublin City, Ireland Intercom Full timeAbout Intercom:At Intercom, we are building the leading AI for customer service. As we continue to push the boundaries of what's possible, we are offering a 6-month Machine Learning Research Fellowship to individuals passionate about joining or advancing the field of AI, and applying cutting-edge research to real-world applications.What's the...
-
Dublin, Ireland The Lakes at Jefferson Full timePostdoctoral Fellow at RCSI: The Royal College of Surgeons in Ireland (RCSI) is seeking a qualified Postdoctoral Fellow to join the School of Population Health and Department of General Practice. This position offers a unique opportunity to work in a multidisciplinary team focused on developing state-of-the-art population-based analytic data systems to...
-
Research Fellow
3 weeks ago
Dublin, Ireland TN Ireland Full timePost SummaryWe are seeking to recruit a Postdoctoral Research Fellow (20 month contract) for the research project ‘INTUIT’. The successful candidate will join an interdisciplinary team of researchers undertaking research in the area of telecommunications development and the environment. The post will be situated in the School of Engineering, Trinity...
-
Postdoctoral Fellow
2 days ago
Dublin, Ireland RCSI Full timePost Date : 22-May-2024Close Date : 23-Jun-2024 Title: Postdoctoral Fellow Department: School of Population Health/Dept of General Practice, RCSI Tenure: Specified Purposes Contract for up to 24 months Salary: Appointable at Post-Doctoral Level 2b Scale Location: St Stephen’s Green, Dublin 2 Reporting to: Professor Kathleen Bennett / Professor...
-
Dublin, Ireland DALLAS VA RESEARCH CORPORATION Full timeResearch Fellow in Organic Chemistry: Trinity College Dublin’s School of Chemistry invites applications for a postdoctoral position within the Porphyshape project, focusing on the Molecular Engineering of Functional Organic Materials. This SFI funded project, led by Prof. Mathias O. Senge, aims to challenge conventional limitations of metalloporphyrins by...
-
Postdoctoral Fellow
2 weeks ago
Dublin, Ireland Royal College of Surgeons (RCSI) Full timeJob Title: Postdoctoral Fellow (Parkinson's Disease Experimental Research)Department: Physiology & Medical PhysicsReporting to: Prof Jochen PrehnLocation: RCSI, St. Stephen's Green, Dublin 2, IrelandContract/Duration: Fulltime, contract for up to 23 months.Remuneration: IUA Post-doctoral Researcher Level 1 pt 2Closing Date: 28th Feb 2025RCSI is a community...
-
Dublin, Ireland Dublin Institute For Advanced Studies Full timePostdoctoral Fellowship with the DIAS Solar Physics GroupApplications are invited for a Postdoctoral Fellowship at the Dublin Institute for Advanced Studies (DIAS) in the Astronomy & Astrophysics Section working with the Solar Physics and Space Weather group.The Astronomy & Astrophysics Section is a vibrant and inclusive community of researchers working on...
-
Postdoctoral Fellow
2 weeks ago
Dublin, Ireland Royal College of Surgeons (RCSI) Full timeJob Title: Postdoctoral Fellow (Parkinson's Disease Computational Research)Department: Physiology & Medical PhysicsReporting to: Dr Niamh ConnollyLocation: RCSI, St. Stephen's Green, Dublin 2, IrelandContract/Duration: Fulltime, contract for up to 23 months.Remuneration: IUA Post-doctoral Researcher Level 1 pt 2Closing Date: 28th Feb 2025RCSI is a community...
-
Ad Astra Fellow
2 weeks ago
County Dublin, Ireland University College Dublin (UCD) Full timeApplications are sought for Ad Astra Fellow - Assistant Professor in One Health within the College of Arts and Humanities. Applications are sought for an Ad Astra Fellow in 'One Health', to be based in the UCD School of History, Ireland's pre-eminent centre for historical teaching and research. The School is home to a diverse faculty of scholars with...
-
Ad Astra Fellow
2 weeks ago
Dublin, Ireland Euraxess Full timeOrganisation/Company: University College DublinResearch Field: Arts » OtherResearcher Profile: Leading Researcher (R4)Country: IrelandApplication Deadline: 19 Feb 2025 - 04:03 (UTC)Type of Contract: TemporaryJob Status: Full-timeIs the job funded through the EU Research Framework Programme? Not funded by a EU programmeIs the Job related to staff position...
-
Post-Doctoral Fellow
3 weeks ago
Dublin, Ireland TN Ireland Full timeSocial network you want to login/join with:Post-Doctoral Fellow - Nano-Engineered Biomaterial Delivery System, DublinClient:RCSILocation:Dublin, IrelandJob Category:OtherEU work permit required:YesJob Reference:bdfe67b45fe6Job Views:83Posted:21.01.2025Expiry Date:07.03.2025Job Description:We are seeking to recruit a postdoctoral researcher to join the KK Lab...
-
Ad Astra Fellow
1 week ago
Dublin, Ireland University College Dublin (UCD) Full timeApplications are sought for Ad Astra Fellow - Assistant Professor in One Health within the College of Arts and Humanities. Applications are sought for an Ad Astra Fellow in 'One Health', to be based in the UCD School of History, Ireland's pre-eminent centre for historical teaching and research. The School is home to a diverse faculty of scholars with...
-
Post-Doctoral Fellow
2 days ago
Dublin, Ireland RCSI Full timeSummary of Post We are seeking to recruit a postdoctoral researcher to join the KK Lab in the School of Pharmacy & Biomolecular Sciences/Tissue Engineering Research Group at RCSI. The successful applicant will work primarily on an IRC-SFI funded project entitled “Nano-Engineered Biomaterial Delivery System with Controlled Strontium Release as a...
-
Dublin, Ireland Intercom Full timeAbout Intercom: At Intercom, we are building the leading AI for customer service. As we continue to push the boundaries of what’s possible, we are offering a 6-month Machine Learning Research Fellowship to individuals passionate about joining or advancing the field of AI, and applying cutting-edge research to real-world applications. What's the...
-
Machine Learning Researcher Fellowship
2 days ago
Dublin, Ireland Intercom Full timeAbout Intercom:At Intercom, we are building the leading AI for customer service.As we continue to push the boundaries of what's possible, we are offering a 6-month Machine Learning Research Fellowship to individuals passionate about joining or advancing the field of AI, and applying cutting-edge research to real-world applications.What's the opportunity?This...
-
Machine Learning Researcher Fellowship
2 days ago
Dublin, Ireland Intercom Full timeAbout Intercom:At Intercom, we are building the leading AI for customer service.As we continue to push the boundaries of what's possible, we are offering a 6-month Machine Learning Research Fellowship to individuals passionate about joining or advancing the field of AI, and applying cutting-edge research to real-world applications.What's the opportunity?This...
