Bioconjugation Scientist New
19 hours ago
Cpl in partnership with our client Pfizer are seeking a Bioconjugation Scientist to join the team for an 11 month fixed term contingent contract at their state of the art plant in Dublin, Grange Castle. This is an onsite role.
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
What You Will Achieve
As a Bioconjugation Scientist, you will be at the centre of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will provide science and technology expertise in the disciplines of bio-conjugation and macromolecule purification sciences for the development and optimization of antibody-drug conjugate (ADC) and vaccine manufacturing processes. You will help Pfizer develop new and improved processes used in the research and development of our drugs. Your innovative mindset will help us develop economical, efficient and safe chemical manufacture of experimental and active drug materials. Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. You are proactive in contributing to all team discussions and creating an environment of collaboration.
It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.
How You Will Achieve It
Pfizer's Sterile and Biotech Technology portfolio comprises multiple approaches for the creation of effective bio therapeutics. Core to these technologies are chemical conjugation steps where immunogenic molecules such as polysaccharides or cytotoxic, small molecules are covalently linked to other carrier/adjuvant molecules.
This laboratory-based role will focus on the characterisation and improvement of these processes for existing vaccines and ADCs in commercial manufacturing, and in the later stages of development programs at Pfizer. The Candidate will -
- Design and execute experimental studies for the development of vaccine and ADC manufacturing processes. Initial focus will concentrate on Process Characterisation and optimisation of process steps for the chemical conjugation of polysaccharides or cytotoxic, small molecules to other carrier/adjuvant molecules and the optimization of purification methodologies for these large molecules.
- Collaborate closely with analytical scientists who will work on the characterisation of these macromolecules during these process development studies.
- Work with the team in the design and optimisation of purification steps for glycoconjugates or other macromolecular vaccines ADCs using technologies such as filtration (normal/tangential flow), chromatography, etc.
- Provide technical support to Drug Substance Technical Services and external contract manufacturing organisations when required during investigations, new process introduction or change implementation in commercial manufacturing operations. Technical support may involve trouble-shooting manufacturing-scale process problems through experimental investigations at laboratory scales of operation.
Qualifications
Must-Have
- Minimum of 0-2 years of experience with a PhD or 1-3+ years’ experience with B.Sc./M.Sc. in the bio pharmaceutical industry.
- BSc/M.Eng/MSc/PhD in chemistry / biochemistry / biochemical engineering / analytical sciences or related discipline in the biochemical/manufacturing sciences.
- Technical fields of experience preferably to include specific knowledge and practical experience of large molecule bio processing and separation sciences gained at a minimum at BEng or BSc level or through work experience.
Nice-to-Have
- Experience in designing and executing components of experimental programs in the laboratory.
- Familiar with problem-solving, risk analysis and statistical tools.
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