mRNA Technology Scientist

7 hours ago

Dublin, Ireland Cpl Resources Full time

Cpl in partnership with our client Pfizer are seeking an mRNA Technology Scientist to join the team at their state of the art plant in Dublin, Grange Castle for an 11 month Fixed Term Contract. This is an onsite role. mRNA Technology Scientist What You Will Achieve As a Scientist, you will be at the centre of our operations and youll find that everything we do, every day, is in line with an unwavering commitment to quality. You will provide science and technology expertise in the disciplines of messenger RNA (mRNA) in-vitro transcription and purification sciences for the development and optimization of vaccine manufacturing processes.You will help Pfizer develop new and improved processes used in the research and development of our drugs. Your innovative mindset will help us develop economical, efficient and safe chemical manufacture of experimental and active drug materials. Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. You are proactive in contributing to all team discussions and creating an environment of collaboration. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe. How You Will Achieve It *Pfizer's Large Molecule Technology portfolio comprises multiple approaches for the creation of effective bio therapeutics. Technology advances have facilitated development of mRNA vaccines which are now a core component of Pfizers product portfolio. mRNA vaccines have the potential to allow faster and more effective responses to infectious disease outbreaks. *This laboratory-based role will focus on the characterization and improvement of these processes for existing mRNA vaccines in commercial manufacturing, and in the later stages of development programs at Pfizer. The Candidate will; oDesign and execute experimental studies for the development of mRNA vaccine including process characterization and optimization of process steps for plasmid DNA, mRNA drug substance and drug product manufacturing processes. oCollaborate closely with analytical scientists who will work on the characterization of these macromolecules during these process development studies. oWork with the team in the design and optimization of purification steps for mRNA vaccines using technologies such as filtration (normal/tangential flow), chromatography, etc. oProvide technical support to Drug Substance Technical Services when required during investigations, new process introduction or change implementation in commercial manufacturing operations.Technical support may involve trouble-shooting manufacturing-scale process problems through experimental investigations at laboratory scales of operation. Qualifications Must-Have *Minimum of +1 years experience with a PhD or +3 years experience with B.Sc./M.Sc. in the bio pharmaceutical industry. *BSc/M.Eng/MSc/PhD in chemistry /biochemistry / biochemical engineering/ analytical sciences or related discipline in the biochemical/manufacturing sciences. *Technical fields of experience preferably to include specific knowledge and practical laboratory experience of mRNA bio processing and separation sciences, mammalian cell technology, biochemistry, cell biology, microbial fermentation, genetics, fluid mechanics and process modelling gained at a minimum at PhD level or through work experience. *Experience in designing and executing components of experimental programs in the laboratory. *Familiar with problem-solving, risk analysis and statistical tools Work Location Assignment:On Premise Skills: mammalian cell technology biochemistry cell biology microbial fermentation genetics fluid mechanics process modelling

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