Research Fellow in Inflammation Biology

3 weeks ago


Dublin, Dublin City, Ireland Trinity College Dublin Full time

Post Summary

The Johnston lab is currently conducting research on the biology of the skin condition, hidradenitis suppurativa (HS). HS has a significant impact on society, causing both psychological distress and physical symptoms in patients. Current treatment options are limited, with many patients showing no response to primary therapies like anti-TNF antibodies.

  • This project aims to investigate the impact of mutations in genes related to the inflammasome pathway, identified through exome sequencing conducted by our partners at New York University (USA). Inflammasomes regulate the production of pro-inflammatory cytokines, including interleukin (IL)-1b and IL-18, which are excessively produced in HS.

The goal is to enhance our understanding of how these mutations function and develop more effective treatments tailored to HS patients, ultimately enhancing their care through precision medicine.

Application Procedure


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