Postdoctoral Fellow

3 weeks ago


Dublin, Dublin City, Ireland RCSI Full time

Summary of Post:

  • We are looking for a postdoctoral researcher to join the Cardiovascular Infection Research Group at RCSI.
  • The selected candidate will work on an NIH-funded project investigating the molecular mechanisms of heart valve damage in Infective Endocarditis.

Project Overview:

  • Infective endocarditis is a serious infection that poses a risk to the heart's inner lining and valves.
  • This condition occurs when harmful microorganisms enter the bloodstream and attach to the heart valves or other cardiac areas.
  • These microorganisms can rapidly multiply, leading to the formation of infected masses called vegetations, which can harm heart tissues and disrupt blood flow.
  • Key symptoms of infective endocarditis include fever, fatigue, and heart murmurs.
  • Timely diagnosis and treatment are crucial to prevent severe complications like heart failure, stroke, or sepsis.
  • Heart valves are commonly affected due to their lack of dedicated blood supply, limiting immune responses and drug delivery.
  • Understanding the molecular interactions within heart tissues is vital for better patient outcomes and the development of innovative therapeutics.
  • The goal is to enhance our understanding of bacterial infection response in heart valves using 3D models to facilitate improved therapies.
  • Platelets and valvular endothelial cells play crucial roles in infective endocarditis, offering potential targets for novel treatments.

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