Dissolution Testing

4 weeks ago

Dublin, Dublin City, Ireland Tentamus Group Full time

Dissolution testing is a laboratory technique used to assess how quickly a solid dosage form dissolves in a specified solvent, mimicking conditions within the gastrointestinal tract. This process helps determine the rate and extent of drug release, impacting its absorption and therapeutic effectiveness.

Dissolution testing plays a vital role in pharmaceutical development and quality assurance for several reasons:

Optimising Drug Formulations

By evaluating dissolution profiles, manufacturers can optimise drug formulations to ensure consistent release characteristics and therapeutic efficacy.

Ensuring Batch-to-Batch Consistency

Dissolution testing helps maintain uniformity in drug performance across different batches, ensuring consistent therapeutic outcomes for patients.

Regulatory Compliance

Regulatory authorities, such as EMA, require dissolution testing data to assess the quality, safety, and efficacy of pharmaceutical products, making it a critical component of regulatory submissions.

Assessing Bioavailability

The rate and extent of drug dissolution directly impact its bioavailability, influencing its pharmacokinetic profile and clinical effectiveness.

To conduct dissolution testing effectively, several key steps are involved:

Sample Preparation

Solid dosage forms are prepared according to standardized procedures to ensure uniformity and accuracy in testing.

Selection of Dissolution Medium

Choosing the appropriate dissolution medium is crucial and depends on factors such as drug solubility, intended route of administration, and physiological conditions.

Apparatus Setup

Dissolution testing is performed using specialised apparatus such as paddles, baskets, or flow-through cells, simulating different physiological conditions within the gastrointestinal tract.

Controlled Testing Conditions

Testing conditions, including temperature, agitation speed, and sampling intervals, are carefully controlled to ensure reproducibility and accuracy of results.

Analysis of Dissolution Profiles

Samples collected at specified time points are analysed using techniques like UV-visible spectroscopy or chromatography to determine the concentration of the drug in the dissolution medium.

#J-18808-Ljbffr

  • Chemistry Testing

    4 days ago

    Dublin, Dublin City, Ireland Tentamus Group Full time

    We detect and identify visible and sub-visible particles in pharmaceutical products to ensure patient safety and product integrity.Advanced analytical techniques such as FTIR and LC-MS are used to identify unknown substances and verify formulation components.We perform precise quantitative analysis of active pharmaceutical ingredients (API) to confirm label...

  • Chemistry Testing

    4 weeks ago

    Dublin, Dublin City, Ireland Tentamus Group Full time

    We detect and identify visible and sub-visible particles in pharmaceutical products to ensure patient safety and product integrity.Advanced analytical techniques such as FTIR and LC-MS are used to identify unknown substances and verify formulation components.We perform precise quantitative analysis of active pharmaceutical ingredients (API) to confirm label...

  • Pharmaceutical Chemistry Professional

    2 days ago

    Dublin, Dublin City, Ireland beBeePharmaceuticalChemistry Full time €87,934 - €123,456

    Job Title: Pharmaceutical Chemistry SpecialistKey Responsibilities:Perform in-depth analysis of pharmaceutical products to ensure patient safety and product integrity.Conduct advanced analytical techniques such as FTIR and LC-MS to verify formulation components and identify unknown substances.Monitor degradation products and related compounds according to...

  • Pharmaceutical Chemistry Specialist

    4 days ago

    Dublin, Dublin City, Ireland beBeeAnalytical Full time €80,000 - €120,000

    We specialize in delivering high-quality pharmaceutical chemistry services that prioritize patient safety and product integrity.Our Key ExpertiseDetection and identification of visible and sub-visible particles in pharmaceutical products for enhanced quality controlAdvanced analytical techniques for verifying unknown substances and formulation...

  • Chemistry Services Specialist

    7 days ago

    Dublin, Dublin City, Ireland beBeePharmaceutical Full time €60,000 - €100,000

    Pharmaceutical Chemistry ExpertiseWe offer a range of specialized chemistry services to ensure patient safety and product integrity. Our team of experts provides precise analysis, detection, and identification of particles in pharmaceutical products.Our Capabilities:Precise quantitative analysis of active pharmaceutical ingredients (API)Comprehensive...

  • Analytik von Elemental Impurities, Dissolution Testing, Nitrosamine etc.

    4 weeks ago

    Dublin, Dublin City, Ireland Tentamus 2022 Full time

    Im Bereich der physikalisch-chemischen Analyse untersuchen wir Arzneimittel beispielsweise auf Schwebstoffe, Partikelgrö ß e und Farbe oder bestimmen Osmolalität und Flüssigkeitsgehalt.Atomabsorptionsspektrometrie (AAS) und Atomemissionsspektrometrie (AES)mit den Möglichkeiten: Flamme, Lachgas, Graphitrohr, Hydrid und den entsprechenden Aufschlüssen:...

  • 15h Left Analytik von Elemental Impurities, Dissolution Testing, Nitrosamine etc.

    3 weeks ago

    Dublin, Dublin City, Ireland Tentamus 2022 Full time

    Im Bereich der physikalisch-chemischen Analyse untersuchen wir Arzneimittel beispielsweise auf Schwebstoffe, Partikelgrö ß e und Farbe oder bestimmen Osmolalität und Flüssigkeitsgehalt.Atomabsorptionsspektrometrie (AAS) und Atomemissionsspektrometrie (AES)mit den Möglichkeiten: Flamme, Lachgas, Graphitrohr, Hydrid und den entsprechenden Aufschlüssen:...

  • QC Analyst

    4 weeks ago

    Dublin, Dublin City, Ireland Takeda Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...

  • 3 Days Left QC Analyst

    3 weeks ago

    Dublin, Dublin City, Ireland Takeda Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...

  • Qc Senior Analyst

    3 weeks ago

    Dublin, Dublin City, Ireland Takeda Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy NoticeandTerms of Use.I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...