Senior Scientist: Cell Line Development and Gene Therapy

2 weeks ago

Dublin, Dublin City, Ireland Fastnet Full time
Senior Scientist: Cell Line Development and Gene TherapySenior Scientist: Cell Line Development and Gene Therapy

Cell Line Development and Gene Therapy Senior Scientist

FTC

South Dublin

Our biopharmaceutical research client in Dublin is looking for a Senior Scientist to support and drive Biologics (mAB and recombinant proteins) and Gene Therapy research and development. These dynamic and exciting areas of research have rapidly expanded in recent years, offering novel and real-world treatment options for patients suffering from recalcitrant and life-limiting conditions.

RESPONSIBILITIES

  • Attending scheduled training and developing expertise in relevant instrumentation and techniques.
  • Developing and validating methods and Standard Operating Procedures.
  • Performing experiments with high precision, reproducibility, quality control and validation.
  • Generating and completing records, with precision and accuracy in a timely manner.
  • Troubleshooting experimental issues and bottlenecks to facilitate continued process and operational improvement.
  • To design and optimise vectors for biologics and ATMP applications.
  • To develop and validate methods for improved Biologics and Gene Therapy generation, performance, efficacy and applicability across a broader spectrum of applications.
  • To provide leadership and mentorship in experimental design and development of robust project structures and plans.
  • To provide leadership for establishment of efficiencies and operational excellence in laboratory operations.
  • To support and develop project opportunities with academic and industry groups for advancement of biologics research and ATMP research.
  • To generate and present publication-ready protocols, data and reports to stakeholders collaborators and clients.
  • To represent the client at conferences and forums and to engage relevant stakeholders regarding ongoing research and development opportunities.
  • To provide considered advice regarding engagement with pan-European consortia and other large groups in the Biologics and Gene Therapy space.

REQUIREMENTS

  • PhD in biotechnology cell biology, molecular biology or another relevant field.
  • Research experience or industrial experience in biotechnology or biopharmaceuticals is required.
  • A strong record in Biologics and Gene Therapy development and characterisation.
  • Significant experience in cloning and vector design work.
  • Excellent cell culture skills, including CHO and HEK cell culture.
  • Demonstrated expertise developing mammalian expression technologies for the generation of monoclonal antibodies, recombinant proteins and / or multi-specific proteins.
  • Experience in Biologics development using a wide range of expression platforms.
  • Experience of mammalian cell line optimisation, clone isolation, characterisation, and banking.
  • Experience in antibody characterisation techniques for assessment of kinetics, affinity and competitive binding using SPR or other techniques.
  • Experience in RT-PCR, dPCR, Sanger or other types of sequence characterisation.
Seniority level
  • Seniority levelMid-Senior level
Employment type
  • Employment typeContract
Job function
  • Job functionResearch and Science
  • IndustriesPharmaceutical Manufacturing and Biotechnology Research

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