Postdoctoral Researcher

3 days ago

Dublin, Ireland EURAXESS Ireland Full time

RCSI - Royal College of Surgeons in Ireland

Organisation/Company RCSI - Royal College of Surgeons in Ireland Department Human Resources Research Field Medical sciences » Cancer research Researcher Profile Recognised Researcher (R2) Positions PhD Positions Country Ireland Application Deadline 30 Nov 2025 - 23:45 (Europe/Dublin) Type of Contract Temporary Job Status Full-time Hours Per Week 39 Is the job funded through the EU Research Framework Programme? Other EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Objective of the Post:

We are seeking a postdoctoral researcher to join our brain tumour research group in the Department of Physiology & Medical Physics. The most common and aggressive primary brain tumour is glioblastoma (GBM). Despite intense effort to combat GBM with surgery, radiation and chemotherapy, 90-95% of patients succumb to the disease within 5 years of diagnosis and nearly all patients experience disease recurrence, usually within 6-8 months of treatment onset. It is now essential that new, better, more‑targeted treatments are properly assessed in robust brain tumour models.

Our Research Ireland‑funded project GLIOTRAT aims to assess the clinical applicability of cyclin‑dependent kinase inhibitors (CKIs) as a novel treatment option for GBM patients. By combining 3D cultures, cancer stem cell populations, large scale high‑content screening, and advanced imaging techniques this integrative translational project will comprehensively examine the therapeutic potential of CDK inhibitors as a treatment strategy for GBM patients.

Specifically the duties of the post will include:

- Lead the radiation biology work‑stream within our GLIOTREAT project to develop and optimize radiation protocols

- Design and execute combination treatment studies involving radiation in 3D gliomasphere cultures

- Implement high‑content imaging workflows for cell death and mechanistic analyses post‑radiation.

- Collaborate with multidisciplinary teams and present findings in high‑impact forums

Qualifications:

- A PhD (or equivalent) in cancer biology, molecular biology or a closely related field.

- Strong publication record and ability to work independently in a collaborative environment

Knowledge & Experience – (Essential):

- Proven experience in radiation delivery systems and safety compliance.

- Strong background in cell culture (preferably 3D models) and mechanistic assays.

- Proficiency in imaging and data analysis tools (e.g., CellProfiler, ImageJ).

Knowledge & Experience (Desirable):

- Knowledge of cancer biology and therapeutic resistance mechanisms.

- Experience with oxygen‑controlled culture systems and high‑content screening platforms

We are all too aware that imposter syndrome and the confidence gap can sometimes stop fantastic candidates from putting themselves forward, so please do submit an application — we’d love to hear from you.

Application Process

Please apply online through the RCSI careers portal before 23:45pm on Sunday 30th of November with your CV and cover letter: www.rcsi/careers.

Informal Enquiries

Informal enquiries are invited in the first instance through Florencia Raimondo, Human Resources Department (email: florenciaraimondo@rcsi.com). All applications for this post must be made through the career's webpage www.rcsi/careers. Florencia can arrange for relevant queries to be addressed by the hiring manager. Please note we do not accept CVs directly.

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